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One ordinary man's quest to become a serious man. Physics professor Larry Gopnik can't believe his life. His wife is leaving him for his best friend, his unemployed brother won't move off the couch, someone is threatening his career, his kids are a mystery and his neighbor is tormenting him by sunbathing nude. Struggling to make sense of it all, Larry consults three different rabbis and their answers lead him on a twisted journey of faith, family, delinquent behavior, and mortality.